ProLegoDB's, statistically significant topologies can be used, by running the local version of proLego. The implementation details can be found with the git hub repository (as mentioned below). This can also used if you have ensemble of structures. The output result will be in a JSON format with topology information as well as module information.
Code can be downloaded from GitHub repository.
T. Khan, S. K. Panday, and I. Ghosh, “ProLego: Tool for extracting and visualizing topological modules in protein structures,” BMC Bioinformatics, vol. 19, no. 1, 2018.